Octreotide treatment associated with adrenal suppression and poor feeding.
نویسنده
چکیده
Response to venepuncture for monitoring in primary schools EDrroR,-We welcome the commentaries that followed our paper that was published in May.' We think, however, that we need to clarify some of the points made in these commentaries to represent the views of the team members. The last sentence of our paper can be easily misinterpreted as conveying the idea that venepuncture is ethically acceptable if the scientific merit of the question is important and the methodology of the study is sound. We hope that the readers will be convinced after reading our paper that, in the conduct of the study, we were satisfied that information was available to the children's parents in the study, that discomfort and the potential risks to the participants were minimal or negligible, and that parents and children were free to decide whether they wanted to participate in the study and free to withdraw from the study at any time, even after signing a consent form. The scientific merit of the research is an important criterion to consider in addition to honest information, minimal distress to participants, and freedom to withdraw from the study at any time. Professor Cockbum's commentary may be interpreted as if we were challenging the Department of Health's circular on local research ethics committees (1991)2 and the MRC document on the ethical conduct of research in children (1991).3 Neither document was available when we planned the pilot study and came to our attention after the pilot study was carried out in May 1992. In my judgment we did not contravene the MRC document because they explicitly include 'to obtain blood specimens' as an example of activity associated with negligible risk. It is worth commenting that for a long time we were reluctant to include venepuncture as part of our nutritional monitoring system. However, as the Department of Health was keen to harmonise, as far as possible, the information obtained from the range ofhealth surveys they are funding, we carried out the pilot study. The main reason for conducting the pilot study was to convince ourselves that the inclusion of blood sampling in our main study would be acceptable to parents, children, and teachers. We were very critical of the decision of the BPA to classify venepuncture as a low risk procedure.4 We were relieved by Professor Hull's clarification that in experienced hands, venepuncture is a minimal risk procedure. One of our three …
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ورودعنوان ژورنال:
- Archives of disease in childhood
دوره 70 6 شماره
صفحات -
تاریخ انتشار 1994